Organic anion transporter drugs
Aims WitrynaDrug transport has been discussed in Chapter 14, and transporter proteins play an important role both in the absorption and in the hepatobiliary and urinary excretion of xenobiotics. The two major classes of drug transporters are the uptake and efflux transporters. Uptake carriers, such as H + /ditripeptide transporter, organic anion ...
Organic anion transporter drugs
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Witryna1 mar 2024 · The family of organic anion transporters (OATs) includes a group of over 10 transmembrane transporting proteins belonging to the solute carrier 22 subfamilies of the major facilitator superfamily. ... New insight into organic anion transporters from the perspective of potentially important interactions and drugs toxicity J Physiol … Cyclosporin A (CyA) has potent inhibitory activity on organic anion transporting polypeptide 1B (OATP1B), causing drug–drug interactions ...
WitrynaThe organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a … Witryna1 lip 2012 · Organic anion transporters play an essential role in the distribution and excretion of numerous endogenous metabolic products and exogenous organic …
Witryna2 sie 2010 · Organic anion transporting polypeptides (OATPs) are uptake transporters for a broad range of endogenous compounds and xenobiotics. To investigate the physiologic and pharmacologic roles of OATPs of the 1A and 1B subfamilies, we generated mice lacking all established and predicted mouse Oatp1a/1b transporters … WitrynaIn vitro–in vivo extrapolation based on uptake clearance determined in human hepatocytes has been used to predict in vivo hepatic clearance of organic anion transporting polypeptide (OATP) substrates. This study evaluated the relative activity factor (RAF) approach to extrapolate active uptake clearance in transporter …
The OATPs play a role in the transport of some classes of drugs across the cell membrane, particularly in the liver and kidney. In the liver, OATPs are expressed on the basolateral membrane of hepatocytes, transporting compounds into the hepatocyte for biotransformation. A number of drug-drug interactions have been associated with the OATPs, affecting the pharmacokinetics and pharmacodynamics of drugs. This is most commonly where one drug inhi…
Witryna1 sty 2015 · The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of attention because of its role in handling of common drugs (antibiotics, antivirals, diuretics, nonsteroidal anti-inflammatory drugs), toxins (mercury, aristolochic acid), … new town williamsburg va hoaWitrynaThe sulfate-anion antiporter 1 (SAT-1; hsat-1) may also contribute to organic anion transport at the basolateral membrane. On the apical membrane, the multi-drug … might be or may be differenceWitrynaThe ability of an antineoplastic drug to exert its cytostatic effect depends largely on the balance between its uptake into and extrusion from the cancer cells. ... the organic … might be or maybeWitrynaOrganic Anion Transporters. Organic anion transporters (OATs) are the secondary/tertiary active transporter proteins that regulate anion balance in the … might be of your interestWitryna8 cze 1999 · Our results show that MRP3 is an organic anion transporter and transports DNP-GS, like MRP1 and MRP2. Moreover, MRP3 can cause resistance to … newtown wine and spiritsWitrynaCommon to all so far functionally characterized Organic Anion Transporters (OATs) is their broad substrate specificity and their ability to exchange extracellular … might be othersWitrynaOrganic anion transporters (OATs) translocate drugs as well as endogenous substances and toxins. The prototype, OAT1 (SLC22A6), first identified as NKT in … new town williamsburg va oxford