Mechanisms of action of n-nitroso compounds
WebDec 1, 1988 · In this review we describe the mechanisms of the inhibitory effects of various chemical agents towards the mutagenicity of N-nitroso compounds, including direct … WebIn this chapter, we will discuss the occurrence and carcinogenicity of nitrosamines, the enzyme mechanisms and the organ site of the activation, and the dose-response …
Mechanisms of action of n-nitroso compounds
Did you know?
WebThere is now convincing evidence that the biological activity of N-nitroso compounds in humans does not differ substantially from that in experimental animals. We can therefore … WebOct 31, 2024 · Because of their cytotoxic properties, N-nitroso compounds are used in cancer therapy. N-nitrosamines are metabolised, and reactive species can be formed that damage the DNA. Therefore, scavenging mechanisms, DNA repair and damage responses are important defence mechanisms, modulating the dose response of these substances.
WebThe N-nitrosamides are unstable at physiological pH and decompose non-enzymatically to a reactive intermediate capable of reacting with cellular macromolecules. The N … WebJan 1, 2014 · NOCs are formed following the ingestion of nitrite. The mechanism responsible for this is the electron exchange reaction involving amines and nitrogen oxides; this occurs most efficiently when at...
WebThe properties of N-nitroso compounds (NNC) and of vitamins C and E are briefly described. The author reviews the ability of vitamins C and E to inhibit NNC formation in chemical systems, in nitrite-preserved meat, in experimental animals and in humans. Dietary vitamins C and E both produced 30% to 60% inhibitions in most carcinogenesis ... WebMany primary alkyl N-nitroso compounds, such as CH3N(H)NO, tend to be unstable with respect to hydrolysis to the alcohol. Those derived from secondary amines (e.g., (CH3)2NNOderived from dimethylamine) are more robust. It is these N-nitrosamines that are carcinogens in rodents. Nitrosyl in inorganic chemistry[edit] Linear and bent metal nitrosyls
WebNov 25, 2024 · N-nitroso compounds (NOC) are produced by the acid catalyzed reaction of nitrite with certain nitrogen compounds. The gastrointestinal tract (GI) is the main site for the formation of...
Web• The organotropic action of NOC is a characteristic feature of this class of compounds: tumors can be specifically induced in target organs, including lung, nasal cavity, … fimfiction falloutWebOct 31, 2024 · Because of their cytotoxic properties, N-nitroso compounds are used in cancer therapy. N-nitrosamines are metabolised, and reactive species can be formed that … grumpy old fart t shirtWebThe NOCs can be divided into two classes: N-nitrosamines and N-nitrosamides and related compounds. N-Nitrosamines are N-nitroso derivatives of secondary amines (Figure 1A); N … fimfiction dreamworks trollsWebN-Nitrosamines: 15 Listings R1 N R2 N O Generic N-nitrosamine structure N-Nitrosamines are a class of chemical compounds with the general structure shown above. The essential feature of N‑nitroso compounds is the N–N=O structure; the R 1 and R 2 groups attached to the amine nitrogen may range from a simple hydrogen (H) atom to more com- fimfiction eeveeWeb3-nitroso-3-azabicyclo[3.1.0]hexane, also known as N-nitroso norharmane, is a heterocyclic compound that has been of interest to scientists due to its potential biological and pharmaceutical properties. In this paper, we aim to provide a comprehensive review of 3-nitroso-3-azabicyclo[3.1.0]hexane, including its definition and background ... grumpy old gits guide to lifeWebThe chemical class of N-nitroso compounds includes the N-nitrosamines, N-nitrosamides and N-nitrosamidines, many of which have been demonstrated to be carcinogenic, mutagenic and teratogenic in various animal species. The N-nitrosamides are unstable at physiological pH and decompose non-enzymatically to a reactive intermediate capable of ... fimfiction emperor of mankindWebR.A. Scanlan, in Encyclopedia of Food Sciences and Nutrition (Second Edition), 2003 Carcinogenicity. Although N-nitroso compounds have been shown to be acutely toxic, mutagenic, and teratogenic, their carcinogenic properties are of grave concern and have been studied extensively. Over 300 N-nitroso compounds, including many nitrosamines, … fimfiction editor technical difficulties