Hepatic nkt
Web1 nov. 2012 · Hepatic inflammation was induced when mice immunized with DC/Hepa1-6 were treated with α-GalCer instead of IL-12 ... et al. Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gamma. Eur J Immunol. 2003; 33:1830–1838. [Google ... WebHepatic inflammation is a key pathological feature of Nonalcoholic Steatohepatitis (NASH). Natural Killer T-cells (NKT) and CD8+ T-cells are known to play an important …
Hepatic nkt
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Web17 nov. 2009 · Natural killer T (NKT) cells are a distinct T lymphocyte lineage that are rapidly activated to produce cytokines that influence many cell types either upon recognition of antigen or in inflammatory settings, allowing them to functionally link the innate and adaptive immune responses ( 1 – 3 ). Web11 apr. 2024 · During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological condition caused by virus-induced liver damage. The activation of hepatic …
Web25 aug. 2000 · It has been established that α‐galactosylceramide (α‐GalCer), a glycolipid, is recognized by natural killer T (NKT) cells together with the monomorphic MHC‐like … Web15 feb. 2006 · Adoptive transfer of wild-type or ob/ob-derived regulatory NKT cells led to a 12% decrease in hepatic fat content. A significant histological shift from macrosteatosis to microsteatosis was observed. Marked improvement in the GTT was noted in wild-type or ob/ob-derived NKT recipients.
WebIt has been established that alpha-galactosylceramide (alpha-GalCer), a glycolipid, is recognized by natural killer T (NKT) cells together with the monomorphic MHC-like … Web15 feb. 2009 · Abstract. NKT cells have been described as innate regulatory cells because of their rapid response to conserved glycolipids presented on CD1d via their invariant …
WebBlockage of CD1d-NKT cell interaction considerably alleviated NKT cell activation and their inhibitory effect on regenerating hepatocytes. Neutralization of IFN-gamma enhanced …
Web15 jan. 2004 · Preclinical models show that activation of Vα24 + Vβ11 + NKT cells induces effective antitumor immune responses and potentially important secondary immune effects, including activation of conventional T cells and NK cells. We describe the first clinical trial of cancer immune therapy with α-GalCer–pulsed CD1d-expressing dendritic cells. lilian lohre kelownaWeb2 mei 2000 · Hepatic NKT cells and T cells constitutively expressed Fas at high level, whereas NK cells expressed a lower level of Fas. The Fas expression on these cells was not elevated 2 h after Con A injection. Figure 4 Expression of FasL and Fas on hepatic MNC subpopulations with or without Con A injection. lilian lyrics insomniumWeb20 mei 2024 · Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models, we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer... lilian mauthoferlilian mathieu thèseWebNKT cells (natural killer T-cells) are an important, but relatively poorly understood, component of the innate immune response. Moreover, NKT cells are enriched within … lilian lightWebHepatic mononuclear cells (HMNC) were isolated and labeled using a minor modification of the method we described previously. 6 Anti-mouse NK1.1-PE, CD3-FITC, CD4-APC, CD8-PerCP, Annexin-V-PE, and 7-AAD were obtained from Pharmingen (San Diego, CA). After surface labeling, HMNC were evaluated by flow cytometry (Becton Dickinson, Palo Alto, … lilian leach singerWeb12 apr. 2024 · Additionally, hepatic NKT cells secreted LIGHT and promoted hepatic steatosis and liver damage, finally resulting in a transition from NASH to hepatocellular carcinoma . In contrast, choline-deficient diet-induced hepatosteatosis decreases the number of NKT cells in the liver in a KC- and IL-12-dependent manner [ 100 ]. lilian knowles